By John J. Langone (Eds.)
The severely acclaimed laboratory general, Methods in Enzymology, is without doubt one of the such a lot hugely revered guides within the box of biochemistry. considering that 1955, every one quantity has been eagerly awaited, often consulted, and praised via researchers and reviewers alike. The sequence comprises a lot fabric nonetheless suitable this day - actually an important ebook for researchers in all fields of lifestyles sciences
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Extra resources for Antibodies, Antigens, and Molecular Mimicry
Krhler, BioTechniques 3, 4040 (1985). J. A. Bluestone, O. Leo, S. L. Epstein, and D. H. Sachs, Immunol. Reo. 90, 1 (1986). 91 F. G. C. M. UytdeHaag, H. Bunschoten, K. Weijer, and A. D. M. E. Osterhaus, Immunol. Rev. 90, 93 (1986). 92 R. W. Finberg and H. C. J. Ertl, Immunol. Rev. 90, 129 (1986). 93 H. Koprowski, D. Herlyn, M. Lubeck, E. DeFreitas, and H. F. Sears, Proc. Natl. Acad. Sci. A. 81, 216 (1984). G. T. Nepom, K. A. Nelson, S. L. Holbeck, I. Hellstrrm, and K. E. HeUstrrm, Proc. Natl. Acad.
Certainly this can be said about the concept of the so-called internal image. It was conceived as a three-dimensional shape mimicry creating an idiotypic structure which resembles the shape of an external antigen. ~9-2~ Shortly after these ideas had been proposed, anti-idiotypes were screened for paratopic specificity and used to induce specific immune resporlses. 28,68,~5°The successful induction of protective immune responses with a special class of anti-idiotypes was considered experimental proof for the internal image concept and also indirectly for the "chemical" view of the network idea.
PoUjak, Science 233, 747 (1986). 34 IDIOTYPES, ANTI-IDIOTYPES, AND MOLECULAR MIMICRY  TABLE II COMPARISON OF JERNEIAN AND NEW ANTIGEN MIMICRY CONCEPTS Jerneian concept New concept Statistical necessity from the idiotype repertoire predicts existence of idiotypic mimicries of external antigens Statistical necessity from network connectivity predicts that the same regulatory interactions are triggered by external antigen and (anti)-idiotypes to produce a specific response Similarity of side-chain and backbone contacts in antigen and (anti)-Id binding All idiotopes are regulatory Shape mimicry of external antigen by anti-Id Existence of regulatory idiotopes as special class Ab2 c~-fl distinction based on inhibition of Id-anti-Id binding by antigen Screening of internal image anti-Id by inhibition studies and response in third party species Internal image anti-Id concept Network antigen defined by affinity and number of network contacts (frequency of idiotope target precursors) Screening of anti-Id expressing network antigens by idiotype "typing and test immunization in relevant species Biological network antigen (epitope) concept Third, to demonstrate this point, experiments have been reported in which an Ab2ot-classified anti-idiotype induced a significant and specific immune r e s p o n s e ) 52'156 In o n e c a s e , 157 the Ab2ct-induced response was not significantly different than the Ab2/3-induced response.
Antibodies, Antigens, and Molecular Mimicry by John J. Langone (Eds.)