Download PDF by A. Bulikova : Antiphospholipid Syndrome

By A. Bulikova

ISBN-10: 9535105264

ISBN-13: 9789535105268

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J Lab Clin Med. 111(5), 519-523. Hunt JE, Simpson RJ & Krilis SA. (1993) Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity. Proc Natl Acad Sci U S A. 90(6), 2141-2145. Ikematsu W, Luan FL, La Rosa L, Beltrami B, Nicoletti F, Buyon JP, Meroni PL, Balestrieri G & Casali P. (1998) Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice. Arthritis Rheum. 41(6), 10261039. Iverson GM, Victoria EJ & Marquis DM.

Impaired thrombin generation in beta 2-glycoprotein I null mice. J Biol Chem 276:13817-13821. , and Koike, T. 2000. Coagulation and fibrinolytic activities in 2 siblings with beta(2)-glycoprotein I deficiency. Blood 96:1594-1595. , et al. 2000. beta(2)-glycoprotein I deficiency: prevalence, genetic background and effects on plasma lipoprotein metabolism and hemostasis. Atherosclerosis 152:337-346. A. 2004. Beta-2 glycoprotein I and its role in antiphospholipid syndrome-lessons from knockout mice.

The American Society of Hematology. Fig. 2. Electron microscopy analysis of β2GPI. , 2010). Analysis of EM pictures showed that more than 99% of plasma β2GPI was in a closed conformation. These observations suggested that plasma β2GPI circulates in a circular (closed) conformation, whereas after interaction with antibodies β2GPI undergoes a major conformational change into a fishhook-like (open) structure. , 1996). When antibodies toward β2GPI were added to plasma, clotting times prolonged in a β2GPI-dependent way.

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Antiphospholipid Syndrome by A. Bulikova

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